Wednesday, June 11, 2008

St. John's Wort Not Effective for ADHD

ADHD affects 3 to 12 percent of children in the United States. Up to 30 percent of these children do not respond to pharmaceutical medications or they have adverse effects such as nausea, insomnia, or weight loss from the medications. For these reasons, many parents seek alternative medicine for their children with ADHD. Complementary or alternative medicine treatments used for pediatric ADHD include massage, dietary changes, dietary supplements, and herbal treatments. In the United States, the most common herbal treatments used by children with ADHD are St John’s wort, Echinacea species, and Ginkgo biloba. Rhodiola rosea has also been reported to have an effect for ADHD.

However, recent research reported on in the June 11th issue of JAMA shows that children and teens with attention-deficit/hyperactivity disorder (ADHD) who were treated with the herb St. John’s wort did not have any greater improvement in ADHD symptoms compared to those who received placebo.

Wendy Weber, N.D., Ph.D., of Bastyr University (Kenmore, WA) and colleagues conducted a clinical trial of St. John’s Wort (Hypericum perforatum) with 54 children and adolescents with ADHD, age 6 to 17 years, to determine whether this agent was effective in lessening the severity of ADHD symptoms. Twenty-seven participants were randomly assigned to receive 300 mg standardized to 0.3 percent hypericin and 27 participants received a matched placebo, three times daily for eight weeks. Other medications for ADHD were not allowed during the trial.

The researchers found that there were no significant differences between the two groups in the change in ADHD rating scale scores from the start of the trial to week 8 and in change in scores rating inattentiveness and hyperactivity. There was also no difference in the proportion of participants who were rated as much or very much improved regarding ADHD symptoms on another measurement scale. No statistically significant difference was found between the two groups in the proportion of participants who experienced rashes, nausea/vomiting, headache, or sunburn during the trial.

“To our knowledge, this is the first placebo-controlled trial of H perforatum in children and adolescents. The results of this study suggest that administration of H perforatum has no additional benefit beyond that of placebo for treating symptoms of child and adolescent ADHD,” the authors write.


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