Monday, December 8, 2008

Wham: The Power of Selenium to Offset Bladder Cancer Risk

Selenium, a trace mineral found in grains, nuts and meats, may aid in the prevention of high-risk bladder cancer. A new study published in the December issue of Cancer Prevention Research, a journal of the American Association for Cancer Research, tells how researchers from Dartmouth Medical School compared selenium levels in 767 individuals newly diagnosed with bladder cancer to the levels of 1,108 individuals from the general population.

Their findings showed an inverse association between selenium and bladder cancer among women, some smokers and those with p53 positive bladder cancer. In the entire study population, there was no inverse association between selenium and bladder cancer. However, looking at the results for several groups, this association was clear. Specifically, this was with women (34 percent reduction in cancer) and moderate smokers (39 percent reduction in cancer). Both groups had significant reductions in bladder cancer with higher rates of selenium.

“There are different pathways by which bladder cancer evolves and it is thought that one of the major pathways involves alterations in the p53 gene,” said author Margaret Karagas, Ph.D., professor at Dartmouth. “Bladder cancers stemming from these alternations are associated with more advanced disease.”

While other studies have shown a similar association between selenium and bladder cancer among women, this study is one of the first to show an association between selenium and this nasty form of bladder cancer.

“Ultimately, if it is true that selenium can prevent a certain subset of individuals, like women, from developing bladder cancer, or prevent certain types of tumors, such as those evolving through the p53 pathway, from developing, it gives us clues about how the tumors could be prevented in the future and potentially lead to chemopreventive efforts,” Karagas said.


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