Wednesday, May 6, 2009

Link Between Overweight Children and Allergies Later in Life

A new study published in the May issue of the Journal of Allergy and Clinical Immunology showed that obese children and adolescents are at increased risk of having some kind of allergy, especially to a food. The study was funded by the National Institute of Environmental Health Sciences (NIEHS) and the National Institute of Allergy and Infectious Diseases (NIAID), both parts of the National Institutes of Health.

“We found a positive association between obesity and allergies,” said Darryl Zeldin, M.D., senior author on the paper. The researchers analyzed data on children and young adults ages 2 to19 from a new national dataset designed to obtain information about allergies and asthma. The size of the data involved makes it the largest nationally representative dataset of allergy and asthma information ever assembled in the United States.

“We have all the pieces of the puzzle in this dataset,” said Zeldin. “The allergy and asthma component of NHANES provides allergen exposure information, allergic sensitization information, as well as disease outcome information. There is a wealth of knowledge we will be able to gain by analyzing these data that will be useful to allergy and asthma sufferers.”

In this study, the researchers analyzed data from 4,111 children and young adults aged 2-19 years of age. They looked at total and allergen-specific immunoglobulin E (IgE) or antibody levels to a large panel of indoor, outdoor and food allergens, body weight, and responses to a questionnaire about diagnoses of hay fever, eczema, and allergies. Obesity was defined as being in the 95th percentile of the body mass index for the child’s age. The researchers found the IgE levels were higher among children who were obese or overweight. Obese children were about 26 percent more likely to have allergies than children of normal weight.

The signal for allergies seemed to be coming mostly from food allergies. The rate of having a food allergy was 59 percent higher for obese children,” said NIEHS researcher Stephanie London, M.D., a co-author on the study.


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